The presence of SigB in Listeria monocytogenes leads to hypersensitivity to hydrogen peroxide under aerobic conditions
نویسندگان
چکیده
Background: SigB is the main stress gene regulator in L. monocytogenes affecting the expression of more than 150 genes and thus contributing in multiple stress resistance. Despite its clear role in most stresses, there is a disambiguation regarding its role against oxidative stress with results ranging from hyperresistance to hypersensitivity that accompanies the loss of sigB. This discrepancy has previously been attributed to strain variability 1 .
منابع مشابه
SigmaB activation under environmental and energy stress conditions in Listeria monocytogenes.
To measure sigmaB activation in Listeria monocytogenes under environmental or energy stress conditions, quantitative reverse transcriptase PCR (TaqMan) was used to determine the levels of transcripts for the sigmaB -dependent opuCA and clpC genes in strains having null mutations in genes encoding regulator of sigma B proteins (rsbT and rsbV) and sigma B (sigB) and in the L. monocytogenes wild-t...
متن کاملIdentification of the gene encoding the alternative sigma factor sigmaB from Listeria monocytogenes and its role in osmotolerance.
Listeria monocytogenes is well known for its robust physiology, which permits growth at low temperatures under conditions of high osmolarity and low pH. Although studies have provided insight into the mechanisms used by L. monocytogenes to allay the physiological consequences of these adverse environments, little is known about how these responses are coordinated. In the studies presented here,...
متن کاملIdentification of the Gene Encoding the Alternative Sigma Factor s from Listeria monocytogenes and Its Role in Osmotolerance†
Listeria monocytogenes is well known for its robust physiology, which permits growth at low temperatures under conditions of high osmolarity and low pH. Although studies have provided insight into the mechanisms used by L. monocytogenes to allay the physiological consequences of these adverse environments, little is known about how these responses are coordinated. In the studies presented here,...
متن کاملThe Effect of Eight Weeks of Aerobic Exercise and Vitamin-D Supplementation on Osteocalcine and Alkaline Pphosphatase in Rats Poisoned with H2O2
Background and Objectives: Osteoporosis is one of the bone diseases that various factors such as oxidative stress have a role in creating it. The current research aimed to examine the synchronous effect of aerobic physical exercise and Vitamin D supplementation on osteocalcine and alkaline phosphatase in rats poisoned by H2O2. Materials & Methods: Sixty adult male Wistar rats were randomly di...
متن کاملThe Listeria monocytogenes Bile Stimulon under Acidic Conditions Is Characterized by Strain-Specific Patterns and the Upregulation of Motility, Cell Wall Modification Functions, and the PrfA Regulon
Listeria monocytogenes uses a variety of transcriptional regulation strategies to adapt to the extra-host environment, the gastrointestinal tract, and the intracellular host environment. While the alternative sigma factor SigB has been proposed to be a key transcriptional regulator that facilitates L. monocytogenes adaptation to the gastrointestinal environment, the L. monocytogenes' transcript...
متن کامل